Phenotypes associated with this allele

• Allele Symbol: Pkd2^tm1.2Tjwt
• Allele Name: targeted mutation 1.2, Terry J Watnick
• Allele ID: MGI:4843127
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd2^tm1.2Tjwt/Pkd2^tm1.2Tjwt	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843163
cn2	Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt Meox2^tm1(cre)Sor/Meox2^+	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843164

Genotype
MGI:4843163

hm1

• Allelic Composition: Pkd2^tm1.2Tjwt/Pkd2^tm1.2Tjwt
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:165114 )

• mice die between E15.5 and E19.5; none are recovered at birth

Genotype
MGI:4843164

cn2

• Allelic Composition: Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

neonatal lethality ( J:165114 )

endocrine/exocrine glands

pancreas cyst ( J:165114 )

cardiovascular system

dextrocardia ( J:165114 )

homeostasis/metabolism

edema ( J:165114 )

• in neonates

growth/size/body

pancreas cyst ( J:165114 )

kidney cyst ( J:165114 )

situs inversus ( J:165114 )

renal/urinary system

kidney cyst ( J:165114 )