Analysis Tools
nervous system
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• in mice never fed doxycycline or fed doxycycline only during development or only during adulthood
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• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in dorsal striatum compared with wild-type mice
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• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in ventral striatum compared with wild-type mice
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• in mice never fed doxycycline but not mice fed doxycycline during adulthood only
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• mice that never received doxycycline exhibit decreased prepulse inhibition compared with wild-type mice
• however, mice that receive doxycycline throughout development or only in adulthood or are treated with haloperidol exhibit normal prepulse inhibition
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• in mice never fed doxycycline but not mice fed doxycycline during adulthood only
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behavior/neurological
| N |
• mice exhibit no change in anxiety-related behavior
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• mice never fed doxycycline exhibit impaired short-term and long-term memory for hippocampus-dependent contextual fear compared with wild-type mice
• mice fed doxycycline only during adulthood or only during the retrieval but not training exhibit reduced levels of contextual fear 24 hours following training compared with wild-type mice
• however, mice fed doxycycline only during development or only after training through retrieval exhibit normal long-term memory for contextual fear
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• mice never fed doxycycline or only fed doxycycline during development but not during adulthood only exhibit impaired spatial learning in a Morris water maze compared with wild-type mice
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• mice never fed doxycycline or only fed doxycycline during development or during adulthood only exhibit impaired spatial memory in a Morris water maze compared with wild-type mice
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• in mice never fed doxycycline or only fed doxycycline during adulthood but not during development only
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:166114 | |
