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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp11cm1Btlr
mutation 1, Bruce Beutler
MGI:4843273
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp11cm1Btlr/Atp11cm1Btlr involves: C57BL/6J MGI:5006843
ht2
 		Atp11cm1Btlr/Atp11cm2Btlr involves: C57BL/6J MGI:5006845
cx3
 		Atp11cm1Btlr/Y
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0 		involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu MGI:5006844
cx4
 		Atp11cm1Btlr/Y
Tg(BCL2)22Wehi/0 		involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi MGI:5006847
ot5
 		Atp11cm1Btlr/Y involves: C57BL/6J MGI:5006842


Genotype
MGI:5006843
hm1
Allelic
Composition		 Atp11cm1Btlr/Atp11cm1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:171925 , J:185495 )
N
• mice exhibit normal fetal B cell lymphopoiesis (J:171925)
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen (J:185495)
decreased B cell number ( J:185495 )
• B cell deficiency

hematopoietic system
decreased B cell number ( J:185495 )
• B cell deficiency




Genotype
MGI:5006845
ht2
Allelic
Composition		 Atp11cm1Btlr/Atp11cm2Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
Atp11cm2Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice

hematopoietic system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice




Genotype
MGI:5006844
cx3
Allelic
Composition		 Atp11cm1Btlr/Y
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes

hematopoietic system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes




Genotype
MGI:5006847
cx4
Allelic
Composition		 Atp11cm1Btlr/Y
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased marginal zone B cell number ( J:171925 )
• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
decreased mature B cell number ( J:171925 )
• as in Atp11cm1Btlr hemizygotes in the bone marrow
decreased follicular B cell number ( J:171925 )
• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes

hematopoietic system
increased marginal zone B cell number ( J:171925 )
• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
decreased mature B cell number ( J:171925 )
• as in Atp11cm1Btlr hemizygotes in the bone marrow
decreased follicular B cell number ( J:171925 )
• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes




Genotype
MGI:5006842
ot5
Allelic
Composition		 Atp11cm1Btlr/Y
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:171925 , J:185495 )
N
• mice exhibit normal allelic exclusion at the immunoglobulin heavy-chain locus (J:171925)
• mice exhibit normal fetal B cell lymphopoiesis (J:171925)
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen (J:185495)
arrested B cell differentiation ( J:171925 )
• mice exhibit cell-intrinsic failure of adult B lymphopoiesis unlike in wild-type mice
decreased B cell number ( J:171925 , J:185495 )
• the percentage of CD19+ B cells in the blood is reduced compared to in wild-type mice (J:171925)
• however, mice exhibit normal numbers of marginal zone B cells and Thy-1.2+ cells (J:171925)
• B cell deficiency (J:185495)
decreased immature B cell number ( J:171925 )
• mice exhibit fewer pre-pro-B cells to pro-B cells compared with wild-type mice
decreased B-1 B cell number ( J:171925 )
• 3-fold in the peritoneal cavity
decreased B-2 B cell number ( J:171925 )
• 10-fold in the peritoneal cavity
decreased IgG1 level ( J:171925 )
• 50% less high-affinity IgG1 antibodies in response to alum-precipitated NP-CGG
decreased IgM level ( J:171925 )
• 50% less NP-specific IgM antibodies in response to NP-ficoll

homeostasis/metabolism

hematopoietic system
arrested B cell differentiation ( J:171925 )
• mice exhibit cell-intrinsic failure of adult B lymphopoiesis unlike in wild-type mice
decreased B cell number ( J:171925 , J:185495 )
• the percentage of CD19+ B cells in the blood is reduced compared to in wild-type mice (J:171925)
• however, mice exhibit normal numbers of marginal zone B cells and Thy-1.2+ cells (J:171925)
• B cell deficiency (J:185495)
decreased immature B cell number ( J:171925 )
• mice exhibit fewer pre-pro-B cells to pro-B cells compared with wild-type mice
decreased B-1 B cell number ( J:171925 )
• 3-fold in the peritoneal cavity
decreased B-2 B cell number ( J:171925 )
• 10-fold in the peritoneal cavity
decreased IgG1 level ( J:171925 )
• 50% less high-affinity IgG1 antibodies in response to alum-precipitated NP-CGG
decreased IgM level ( J:171925 )
• 50% less NP-specific IgM antibodies in response to NP-ficoll




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory