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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp11cm2Btlr
mutation 2, Bruce Beutler
MGI:4843275
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp11cm2Btlr/Atp11cm2Btlr involves: C57BL/6J MGI:5429182
ht2
 		Atp11cm1Btlr/Atp11cm2Btlr involves: C57BL/6J MGI:5006845
ot3
 		Atp11cm2Btlr/Y involves: C57BL/6J MGI:5006846


Genotype
MGI:5429182
hm1
Allelic
Composition		 Atp11cm2Btlr/Atp11cm2Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm2Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen
decreased B cell number ( J:185495 )
• B cell deficiency

hematopoietic system
decreased B cell number ( J:185495 )
• B cell deficiency




Genotype
MGI:5006845
ht2
Allelic
Composition		 Atp11cm1Btlr/Atp11cm2Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
Atp11cm2Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice

hematopoietic system
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice




Genotype
MGI:5006846
ot3
Allelic
Composition		 Atp11cm2Btlr/Y
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm2Btlr mutation (1 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen
decreased B cell number ( J:171925 , J:185495 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice (J:171925)
• B cell deficiency (J:185495)

hematopoietic system
decreased B cell number ( J:171925 , J:185495 )
• the percentage of CD19+ B cells is reduced compared to in wild-type mice (J:171925)
• B cell deficiency (J:185495)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory