mortality/aging
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• all mice that survive past weaning are sick by 42 days of age
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• fewer than expected mice are found at E18.5 and at birth
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• most survivors die before weaning
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neoplasm
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• live born mice develop a variety of benign and malignant tumors
• mice develop tumors in multiple organs
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growth/size/body
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• live born mice are smaller than their control littermates
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integument
respiratory system
nervous system
muscle