Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(sb-Onco-Array)Peli}
• Allele Name: targeted mutation 1, Pentao Liu
• Allele ID: MGI:4843327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(sb11)Njen/Gt(ROSA)26Sor^+ Hprt1^tm1(sb-Onco-Array)Peli/Hprt1^+	involves: 129S7/SvEvBrd	MGI:4843329
cn2	Gt(ROSA)26Sor^tm1(sb11)Njen/Gt(ROSA)26Sor^+ Hprt1^tm1(sb-Onco-Array)Peli/Y	involves: 129S7/SvEvBrd	MGI:4843330

Genotype
MGI:4843329

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; Hprt1^{tm1(sb-Onco-Array)Peli}/Hprt1⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:166283 )

♀ • all mice that survive past weaning are sick by 42 days of age

perinatal lethality, incomplete penetrance ( J:166283 )

♀ • fewer than expected mice are found at E18.5 and at birth

postnatal lethality, incomplete penetrance ( J:166283 )

♀ • most survivors die before weaning

neoplasm

increased tumor incidence ( J:166283 )

♀ • mice develop tumors in multiple organs

♀ • live born mice develop a variety of benign and malignant tumors

increased skin squamous cell carcinoma incidence ( J:166283 )

♀

increased rhabdomyosarcoma incidence ( J:166283 )

♀

increased lung adenoma incidence ( J:166283 )

♀

increased hemangioma incidence ( J:166283 )

♀

increased lymphoma incidence ( J:166283 )

♀

increased medulloblastoma incidence ( J:166283 )

♀

increased lung adenocarcinoma incidence ( J:166283 )

♀

increased hemangiosarcoma incidence ( J:166283 )

♀

growth/size/body

decreased birth body size ( J:166283 )

♀ • live born mice are smaller than their control littermates

postnatal growth retardation ( J:166283 )

♀

integument

increased skin squamous cell carcinoma incidence ( J:166283 )

♀

respiratory system

increased lung adenoma incidence ( J:166283 )

♀

increased lung adenocarcinoma incidence ( J:166283 )

♀

nervous system

increased medulloblastoma incidence ( J:166283 )

♀

muscle

increased rhabdomyosarcoma incidence ( J:166283 )

♀

Genotype
MGI:4843330

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; Hprt1^{tm1(sb-Onco-Array)Peli}/Y
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:166283 )

♂ • all mice that survive past weaning are sick by 42 days of age

perinatal lethality, incomplete penetrance ( J:166283 )

♂ • fewer than expected mice are found at E18.5 and at birth

postnatal lethality, incomplete penetrance ( J:166283 )

♂ • most survivors die before weaning

neoplasm

increased tumor incidence ( J:166283 )

♂ • live born mice develop a variety of benign and malignant tumors

♂ • mice develop tumors in multiple organs

increased skin squamous cell carcinoma incidence ( J:166283 )

♂

increased rhabdomyosarcoma incidence ( J:166283 )

♂

increased lung adenoma incidence ( J:166283 )

♂

increased hemangioma incidence ( J:166283 )

♂

increased lymphoma incidence ( J:166283 )

♂

increased medulloblastoma incidence ( J:166283 )

♂

increased lung adenocarcinoma incidence ( J:166283 )

♂

increased hemangiosarcoma incidence ( J:166283 )

♂

growth/size/body

decreased birth body size ( J:166283 )

♂ • live born mice are smaller than their control littermates

postnatal growth retardation ( J:166283 )

♂

integument

increased skin squamous cell carcinoma incidence ( J:166283 )

♂

muscle

increased rhabdomyosarcoma incidence ( J:166283 )

♂

nervous system

increased medulloblastoma incidence ( J:166283 )

♂

respiratory system

increased lung adenoma incidence ( J:166283 )

♂

increased lung adenocarcinoma incidence ( J:166283 )

♂