Phenotypes associated with this allele

• Allele Symbol: Terb1^{tm1a(KOMP)Mbp}
• Allele Name: targeted mutation 1a, Mouse Biology Program, UC Davis
• Allele ID: MGI:4843634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Terb1^tm1a(KOMP)Mbp/Terb1^tm1a(KOMP)Mbp	C57BL/6-Terb1^tm1a(KOMP)Mbp	MGI:5566676

Genotype
MGI:5566676

hm1

• Allelic Composition: Terb1^{tm1a(KOMP)Mbp}/Terb1^{tm1a(KOMP)Mbp}
• Genetic Background: C57BL/6-Terb1^{tm1a(KOMP)Mbp}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent oocytes ( J:205574 )

♀ • lack mature oocytes

azoospermia ( J:205574 )

♂ • absence of postmeiotic cells in the testes

abnormal female meiosis ( J:205574 )

♀ • defect in telomere-nuclear envelope attachment

abnormal female meiosis I arrest ( J:205574 )

♀ • arrest in the leptotene or zygotene-like stages, prior to full synapsis at E18.5

abnormal male meiosis ( J:205574 )

♂ • homologous pairing and chromosome movement are impaired

♂ • defect in telomere-nuclear envelope attachment

♂ • cohesin enrichment at telomeres over the chromosome axis is reduced and structural abnormalities of the telomeres (i.e. splitting, bridging) are seen

abnormal X-Y chromosome synapsis during male meiosis ( J:205574 )

♂ • disrupted

arrest of male meiosis ( J:205574 )

♂ • arrest either in the leptotene or zygotene-like stages at E18.5

increased male germ cell apoptosis ( J:205574 )

♂ • high prevalence of apoptotic cells in the testes

absent ovarian follicles ( J:205574 )

♀ • lack growing follicles

ovary degeneration ( J:205574 )

♀ • ovary degeneration

female infertility ( J:205574 )

♀

male infertility ( J:205574 )

♂

cellular

absent oocytes ( J:205574 )

♀ • lack mature oocytes

azoospermia ( J:205574 )

♂ • absence of postmeiotic cells in the testes

abnormal female meiosis ( J:205574 )

♀ • defect in telomere-nuclear envelope attachment

abnormal female meiosis I arrest ( J:205574 )

♀ • arrest in the leptotene or zygotene-like stages, prior to full synapsis at E18.5

abnormal male meiosis ( J:205574 )

♂ • homologous pairing and chromosome movement are impaired

♂ • defect in telomere-nuclear envelope attachment

♂ • cohesin enrichment at telomeres over the chromosome axis is reduced and structural abnormalities of the telomeres (i.e. splitting, bridging) are seen

abnormal X-Y chromosome synapsis during male meiosis ( J:205574 )

♂ • disrupted

arrest of male meiosis ( J:205574 )

♂ • arrest either in the leptotene or zygotene-like stages at E18.5

increased male germ cell apoptosis ( J:205574 )

♂ • high prevalence of apoptotic cells in the testes

endocrine/exocrine glands

absent ovarian follicles ( J:205574 )

♀ • lack growing follicles

ovary degeneration ( J:205574 )

♀ • ovary degeneration