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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bckdhatm1a(EUCOMM)Hmgu
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:4843858
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bckdhatm1a(EUCOMM)Hmgu/Bckdhatm1a(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
involves: C57BL/6N * FVB MGI:6361695


Genotype
MGI:6361695
cn1
Allelic
Composition
Bckdhatm1a(EUCOMM)Hmgu/Bckdhatm1a(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bckdhatm1a(EUCOMM)Hmgu mutation (0 available); any Bckdha mutation (35 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures
• in brown adipose tissue following treatment with noradrenaline
• however, muscle response is normal
• after cold exposure without affecting muscle shivering
• prostaglandin E2 (PGE2)-induced febrile response is substantially attenuated relative to controls, with lower total heat production and lower maximum temperature
• however, no difference is seen in the velocity of the initial brown adipose tissue temperature change
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures
• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice

adipose tissue
• in mice fed a high-fat diet at ambient temperatures
• reduced glucose and fatty acid oxidation in brown adipose tissue of mice fed a high-fat diet at ambient temperatures

growth/size/body
• in mice fed a high-fat diet at ambient temperatures despite normal lean mass
• in mice fed a high-fat diet at ambient temperatures

liver/biliary system
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures

behavior/neurological
N
• at ambient temperatures, mice fed a high-fat diet exhibit normal food intake

cellular
• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory