Analysis Tools
mortality/aging
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• pIpC-treated mice die within 14 days unlike similarly treated heterozygous mice
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hematopoietic system
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• pIpC-treated mice exhibit a reduction in nucleated hematopoietic cells and an increase in CD71-Ter119high in the bone marrow cavity compared with similarly treated heterozygous mice
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• bone marrow cells from pIpC-treated mice exhibit reduced colony formation in response to IFN-beta treatment unlike similarly treated cells from heterozygous mice
• however, colony formation in the absence of IFN-beta is normal
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• pIpC-treated mice exhibit a reduction of nucleated cells, B220 B+ cells, and Ter119+ erythroid cells in the bone marrow compared with similarly treated heterozygous mice
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• in pIpC-treated mice
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• pIpC-treated mice exhibit a reduction in Mac1+Gr-1mid-lo monocyte/macrophage lineage and Mac-1+Gr-1hi granulocyte lineage compared with similarly treated heterozygous mice
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• in pIpC-treated mice
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• pIpC-treated mice exhibit an increase in apoptosis compared to in similarly treated heterozygous mice
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