Analysis Tools
homeostasis/metabolism
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• in tamoxifen-treated mice
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• greater than 2-fold in tamoxifen-treated mice due to reduced intestinal absorption
• however, kidney function is normal
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• tamoxifen-treated mice fail to exhibit a change in phosphorus in response to nicotinamide unlike similarly treated control mice
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digestive/alimentary system
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• after 10 week, tamoxifen-treated mice exhibit a 2-fold increase in focal phosphate content compared with similarly treated control mice
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• tamoxifen-treated mice exhibit reduced intestinal absorption of phosphorus compared with similarly treated control mice
• tamoxifen-treated mice fail to exhibit a change in phosphorus in response to nicotinamide unlike similarly treated control mice
• tamoxifen-treated mice exhibit reduced sodium dependent intestinal phosphate transport in the jejunum and ileum compared with similarly treated control mice
• however, tamoxifen-treated mice exhibit normal calcium and sodium-independent phosphate transport
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renal/urinary system
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• in tamoxifen-treated mice
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• greater than 2-fold in tamoxifen-treated mice due to reduced intestinal absorption
• however, kidney function is normal
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respiratory system
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• tamoxifen-treated mice develop calcification nodules in the lungs (pulmonary alveolar microlithiasis) unlike similarly treated control mice
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