Phenotypes associated with this allele

• Allele Symbol: F9^tm3Dws
• Allele Name: targeted mutation 3, Darrel W Stafford
• Allele ID: MGI:4847605
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F9^tm3Dws/F9^tm3Dws	B6.129P2-F9^tm3Dws	MGI:4847608
ot2	F9^tm3Dws/Y	B6.129P2-F9^tm3Dws	MGI:4847611

Genotype
MGI:4847608

hm1

• Allelic Composition: F9^tm3Dws/F9^tm3Dws
• Genetic Background: B6.129P2-F9^tm3Dws

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased bleeding time ( J:166332 )

♀ • mice bleed for 6.5 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice

♀ • mean bleeding time is 7.9 minutes compared with 3.9 minutes for wild-type mice

♀ • bleed times are variable among individual mice

♀ • however, there is no difference in incidence of delayed rebleeding

hematopoietic system

decreased hematocrit ( J:166332 )

♀ • following bleeding experiments

Genotype
MGI:4847611

ot2

• Allelic Composition: F9^tm3Dws/Y
• Genetic Background: B6.129P2-F9^tm3Dws

homeostasis/metabolism

abnormal blood coagulation ( J:166332 )

♂ • thrombi in the mesentery arterioles of ferric chloride-treated mice are slower to form and are more labile than in similarly treated wild-type mice

♂ • however, laser-induced thrombosis in the cremaster muscle arteriole is normal

increased bleeding time ( J:166332 )

♂ • mice bleed for 6.5 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice

♂ • mean bleeding time is 7.9 minutes compared with 3.9 minutes for wild-type mice

♂ • bleed times are variable among individual mice

♂ • however, there is no difference in incidence of delayed rebleeding

hematopoietic system

decreased hematocrit ( J:166332 )

♂ • following bleeding experiments