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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbk1tm1.1Lex
targeted mutation 1.1, Lexicon Genetics
MGI:4847640
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbk1tm1.1Lex/Tbk1tm1.1Lex B6.129S5-Tbk1tm1.1Lex MGI:4847652
hm2
 		Tbk1tm1.1Lex/Tbk1tm1.1Lex involves: 129S4/SvJae * 129S5/SvEvBrd MGI:4847651
ht3
 		Tbk1tm1.1Lex/Tbk1+ involves: 129S4/SvJae * 129S5/SvEvBrd MGI:4847650


Genotype
MGI:4847652
hm1
Allelic
Composition		 Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic
Background		 B6.129S5-Tbk1tm1.1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1tm1.1Lex mutation (0 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:166476 )
• Background Sensitivity: no mice are produced on a C57BL/6 congenic background unlike on a mixed background




Genotype
MGI:4847651
hm2
Allelic
Composition		 Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic
Background		 involves: 129S4/SvJae * 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1tm1.1Lex mutation (0 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:166476 )
• mice exhibit increased susceptibility to LPS-induced lethality compared with similarly treated wild-type mice
prenatal lethality, incomplete penetrance ( J:166476 )
• Background Sensitivity: fewer than expected mice are born

immune system
decreased NK T cell number ( J:166476 )
• mice exhibit reduced CD3+ and CD3+CD8+ T cells compared with wild-type mice
increased NK T cell number ( J:166476 )
• mice exhibit a slight increase in CD3+CD4+ T cells compared with wild-type mice
increased IgA level ( J:166476 )
• 1.5- to 3-fold
lymphoid hyperplasia ( J:166476 )
• in the spleen
decreased interferon-beta secretion ( J:166476 )
• in bone marrow-derived macrophages stimulated with LPS or pIpC
increased interleukin-6 secretion ( J:166476 )
• 2-fold in bone marrow-derived macrophages stimulated with LPS
• however, IL6 production up to 8 hours after LPS stimulation is normal in two subsequent experiments
increased tumor necrosis factor secretion ( J:166476 )
• 2-fold in bone marrow-derived macrophages stimulated with LPS
• however, TNF production up to 8 hours after LPS stimulation is normal in two subsequent experiments
abnormal inflammatory response ( J:166476 )
• mice exhibit increased infiltration of mononuclear and/or granulomatous cells in multiple organs and tissues including lungs, liver, kidney, skin, salivary gland, Hardrian gland, epididymides, and joint synovium compared with wild-type mice
increased susceptibility to endotoxin shock ( J:166476 )
• mice exhibit increased susceptibility to LPS-induced lethality with increased serum levels of IL1b, TNF, IL6, KC, GM-CSF, and IL10 compared with similarly treated wild-type mice
skin inflammation ( J:166476 )
• at 2 weeks of age, most mice exhibit histocytic and/or neutrophilic cellular infiltrates in the skin unlike in wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:166476 )
• mice exhibit increased susceptibility to LPS-induced lethality compared with similarly treated wild-type mice

homeostasis/metabolism
skin edema ( J:166476 )
• at 2 weeks of age

hematopoietic system
decreased NK T cell number ( J:166476 )
• mice exhibit reduced CD3+ and CD3+CD8+ T cells compared with wild-type mice
increased NK T cell number ( J:166476 )
• mice exhibit a slight increase in CD3+CD4+ T cells compared with wild-type mice
increased IgA level ( J:166476 )
• 1.5- to 3-fold

integument
skin inflammation ( J:166476 )
• at 2 weeks of age, most mice exhibit histocytic and/or neutrophilic cellular infiltrates in the skin unlike in wild-type mice
sparse hair ( J:166476 )
• at 3 months of age, especially on the ventral surface
disheveled coat ( J:166476 )
• at 3 months of age, especially on the ventral surface
abnormal hair cycle anagen phase ( J:166476 )
• at 3 months of age, more hair follicles are in anagen phase compared to in wild-type mice
• however, no increase in hair follicles in anagen is observed at 2 weeks of age
abnormal skin morphology ( J:166476 )
• at 2 weeks of age, mice exhibit skin necrosis, increased dermal cellularity, hyperkeratosis, skin hyperplasia, inflammatory cell infiltrates, and edema unlike wild-type mice
skin edema ( J:166476 )
• at 2 weeks of age
dermal hyperplasia ( J:166476 )
• at 2 weeks of age
hyperkeratosis ( J:166476 )
• at 2 weeks of age
skin hyperplasia ( J:166476 )
• at 2 weeks of age

growth/size/body
increased spleen weight ( J:166476 )
• slight




Genotype
MGI:4847650
ht3
Allelic
Composition		 Tbk1tm1.1Lex/Tbk1+
Genetic
Background		 involves: 129S4/SvJae * 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1tm1.1Lex mutation (0 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:166476 )
• mice exhibit more cellular infiltrates in multiple organs and tissues compared with wild-type mice that is not as frequent or severe as in homozygous mice

hematopoietic system




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory