Phenotypes associated with this allele

• Allele Symbol: Tac4^tm1Albe
• Allele Name: targeted mutation 1, Alexandra Berger
• Allele ID: MGI:4847657
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tac4^tm1Albe/Tac4^tm1Albe	B6.129P2-Tac4^tm1Albe	MGI:4847658

Genotype
MGI:4847658

hm1

• Allelic Composition: Tac4^tm1Albe/Tac4^tm1Albe
• Genetic Background: B6.129P2-Tac4^tm1Albe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased pro-B cell number ( J:166471 )

• mice exhibit an increase in fraction B pro-B cells compared with wild-type mice

• bone marrow cells cultured with IL17 exhibit increased pro-B cell numbers compared with similarly treated wild-type cells

• cultured long-term reconstituting cells (LTRCs) contain increased numbers of pro-B cells compared with wild-type cultures

• however, mature B cell production is normal in vivo and in vitro, and HK-1 can suppress pro-B cell development in LTRC-derived cultures

hematopoietic system

increased pro-B cell number ( J:166471 )

• mice exhibit an increase in fraction B pro-B cells compared with wild-type mice

• bone marrow cells cultured with IL17 exhibit increased pro-B cell numbers compared with similarly treated wild-type cells

• cultured long-term reconstituting cells (LTRCs) contain increased numbers of pro-B cells compared with wild-type cultures

• however, mature B cell production is normal in vivo and in vitro, and HK-1 can suppress pro-B cell development in LTRC-derived cultures