Phenotypes associated with this allele

• Allele Symbol: Farp2^tm1Akum
• Allele Name: targeted mutation 1, Atsushi Kumanogoh
• Allele ID: MGI:4847666
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Farp2^tm1Akum/Farp2^tm1Akum	B6.Cg-Farp2^tm1Akum	MGI:4847668

Genotype
MGI:4847668

hm1

• Allelic Composition: Farp2^tm1Akum/Farp2^tm1Akum
• Genetic Background: B6.Cg-Farp2^tm1Akum

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit a smaller number of multinucleated osteoclasts and area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

increased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and increasing concentration of RANKL exhibit an increase in multinucleated osteoclasts but a smaller area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

abnormal osteoclast physiology ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit decreased surface area covered by osteoclasts and resorptive activity compared with similarly treated wild-type cultures

abnormal trabecular bone volume ( J:166376 )

• mice exhibit a slight increase in bone volume to trabecular volume compared with wild-type mice

abnormal bone trabecula morphology ( J:166376 )

• mice exhibit a decrease in trabecular space compared with wild-type mice

increased bone trabecula number ( J:166376 )

• mice exhibit an increase in trabecular number

decreased bone resorption ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit reduced resoprtion pits on calcium phosphate-coated discs compared with similarly treated wild-type cultures

• however, high concentrations of RANKL restores normal numbers of resorption pits

immune system

decreased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit a smaller number of multinucleated osteoclasts and area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

increased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and increasing concentration of RANKL exhibit an increase in multinucleated osteoclasts but a smaller area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

abnormal osteoclast physiology ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit decreased surface area covered by osteoclasts and resorptive activity compared with similarly treated wild-type cultures

hematopoietic system

decreased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit a smaller number of multinucleated osteoclasts and area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

increased osteoclast cell number ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and increasing concentration of RANKL exhibit an increase in multinucleated osteoclasts but a smaller area covered by multinucleated osteoclasts compared with similarly treated wild-type cultures

abnormal osteoclast physiology ( J:166376 )

• bone marrow-derived mononuclear cells cultured with M-CSF and RANKL exhibit decreased surface area covered by osteoclasts and resorptive activity compared with similarly treated wild-type cultures