Phenotypes associated with this allele

• Allele Symbol: Orc1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4847686
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orc1^tm1a(KOMP)Wtsi/Orc1^tm1a(KOMP)Wtsi	C57BL/6N-Orc1^tm1a(KOMP)Wtsi/Wtsi	MGI:5706055
ht2	Orc1^tm1a(KOMP)Wtsi/Orc1^+	C57BL/6N-Orc1^tm1a(KOMP)Wtsi/Wtsi	MGI:6394346

Genotype
MGI:5706055

hm1

• Allelic Composition: Orc1^{tm1a(KOMP)Wtsi}/Orc1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Orc1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0694_5_G11

Data Sources

IMPC Data for Orc1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:6394346

ht2

• Allelic Composition: Orc1^{tm1a(KOMP)Wtsi}/Orc1⁺
• Genetic Background: C57BL/6N-Orc1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0694_5_G11

Data Sources

IMPC Data for Orc1

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - WTSI

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - WTSI

increased bone mineral density ( J:211773 )

♂

IMPC - WTSI