All Phenotypes Sirt6<tm1.1Cxd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sirt6^tm1.1Cxd
targeted mutation 1.1, Chu-Xia Deng
MGI:4847905

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sirt6^tm1.1Cxd/Sirt6^tm1.1Cxd Tg(Alb1-cre)1Dlr/0	involves: 129S6/SvEvTac * FVB/N	MGI:4847910

Allelic Composition	Sirt6^tm1.1Cxd/Sirt6^tm1.1Cxd Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt6^tm1.1Cxd mutation (1 available); any Sirt6 mutation (41 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver morphology ( J:166368 )

increased liver weight ( J:166368 )

hepatic steatosis ( J:166368 )

• beginning at 5 to 6 months of age

homeostasis/metabolism

increased circulating glucose level ( J:166368 )

• slightly after 8 months of age and in an insulin tolerance test

growth/size/body

increased liver weight ( J:166368 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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