Phenotypes associated with this allele

• Allele Symbol: Il6ra^tm1.1Jcbr
• Allele Name: targeted mutation 1.1, Jens C Bruning
• Allele ID: MGI:4847943
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5550556
cn2	Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N	MGI:4847952

Genotype
MGI:5550556

cn1

• Allelic Composition: Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

decreased susceptibility to parasitic infection ( J:188445 )

• mice infected with P. chabaudi exhibit lower IL1b and TNF-alpha levels compared with control mice

• however, lethality is normal

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

Genotype
MGI:4847952

cn2

• Allelic Composition: Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr; Tg(Alb1-cre)7Gsc/0
• Genetic Background: involves: C57BL/6 * FVB/N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166367 )

N • mice exhibit normal leptin levels, respiratory exchange rate, and homeostasis of oxygen and carbon dioxide

decreased insulin secretion ( J:166367 )

• in cultured islets under high glucose conditions

increased insulin secretion ( J:166367 )

• in cultured islets under low glucose conditions

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

increased circulating interleukin-6 level ( J:166367 )

• during the steady state

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

increased circulating tumor necrosis factor level ( J:166367 )

• 2.5-fold

impaired glucose tolerance ( J:166367 )

• mice exhibit impaired glucose tolerance compared with wild-type mice

• however, depletion of TNF or treatment with clodronate liposomes to deplete Kupffer cells normalizes glucose clearance

abnormal glycogen homeostasis ( J:166367 )

• mice exhibit increased hepatic glycogen synthesis and glycogenolysis compared with wild-type mice

increased glycogen catabolism rate ( J:166367 )

• in steady state

decreased liver glycogen level ( J:166367 )

• in steady state, mice exhibit a reduction in hepatic glycogen levels compared with wild-type mice

• however, fasted mice exhibit normal hepatic glycogen levels

insulin resistance ( J:166367 )

• in an insulin tolerance test, insulin treatment fails to lower serum glucose levels as in similarly treated wild-type mice

adipose tissue

adipose tissue phenotype ( J:166367 )

N • mice exhibit normal epigonadal fat pad weight and total body fat content

decreased adipocyte glucose uptake ( J:166367 )

• glucose uptake in white adipose tissue is reduced compared to in wild-type tissue

immune system

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

increased circulating interleukin-6 level ( J:166367 )

• during the steady state

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

increased circulating tumor necrosis factor level ( J:166367 )

• 2.5-fold

decreased susceptibility to parasitic infection ( J:188445 )

• mice infected with P. chabaudi exhibit lower IL1b and TNF-alpha levels compared with control mice

• however, lethality is normal

growth/size/body

growth/size/body region phenotype ( J:166367 )

N • mice exhibit normal body weight

behavior/neurological

behavior/neurological phenotype ( J:166367 )

N • mice exhibit normal food intake and activity levels

liver/biliary system

decreased liver glycogen level ( J:166367 )

• in steady state, mice exhibit a reduction in hepatic glycogen levels compared with wild-type mice

• however, fasted mice exhibit normal hepatic glycogen levels

endocrine/exocrine glands

decreased insulin secretion ( J:166367 )

• in cultured islets under high glucose conditions

increased insulin secretion ( J:166367 )

• in cultured islets under low glucose conditions

cellular

decreased adipocyte glucose uptake ( J:166367 )

• glucose uptake in white adipose tissue is reduced compared to in wild-type tissue