mortality/aging
• following induction with doxycycline associated with marked gut pathology
|
reproductive system
N |
• despite delayed sexual maturation in female mice, fertility over the first 3 months of life is normal
|
• time to first litter is delayed compared with wild-type mice
• however, timing of first estrus is normal
|
• puberty is delayed in female mice compared with wild-type mice
• at P26, uterine plus ovarian mass is less than in wild-type mice indicating delayed sexual development
• however, timing of first estrus is normal
|
• in the first litter
|
growth/size/body
broad face
(
J:166568
)
• mice exhibit wider faces compared with wild-type mice
|
• increase in the percentage of lean mass
|
• gain less fat mass with age compared to wild-type mice on a normal diet
|
• gain less fat mass when fed a high fat diet compared to wild-type mice
• no difference in the consumption of high fat food is detected
|
• regardless of doxycycline induction
|
• after weaning
|
• after weaning
|
• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size
|
homeostasis/metabolism
• gain less fat mass when fed a high fat diet compared to wild-type mice
• no difference in the consumption of high fat food is detected
|
• in fed and fasted states
|
• after glucose stimulation
|
• without increased insulin secretion
(J:166568)
• under high fat diet conditions
(J:177113)
|
• under high fat diet conditions
(J:177113)
|
skeleton
• mice exhibit large bones compared with wild-type mice
• mice exhibit bone hyperplasia compared with wild-type mice
|
• bone mineral content is increased compared to in wild-type mice
|
• bone mineral density is increased compared to in wild-type mice
|
craniofacial
broad face
(
J:166568
)
• mice exhibit wider faces compared with wild-type mice
|
liver/biliary system
• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size
|
• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size
|
• under high fat diet conditions
|
cellular
• doxycycline-treated mice exhibit an increase in cell proliferation in the intestinal crypts, blood, and skin compared with wild-type mice
• mice exhibit cell hyperplasia without an increase in cell size
|
• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size
|
digestive/alimentary system
• following induction with doxycycline, mice exhibit marked gut pathology unlike wild-type mice
|
hearing/vestibular/ear
endocrine/exocrine glands
integument
coarse hair
(
J:166568
)
thick skin
(
J:166568
)
adipose tissue
• decrease in the percentage of body fat
|