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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(PDGFB)Cbet
targeted mutation 1, Christer Betsholtz
MGI:4849447
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4849465
cn2
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4849467
cn3
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL MGI:4849464
cn4
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL MGI:4849466


Genotype
MGI:4849465
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Fabp4-lacZ)4Mosh mutation (1 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166532 )
• mural cell (pericytes and vascular smooth muscle cells) densities are lower than in wild-type mice




Genotype
MGI:4849467
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Fabp4-lacZ)4Mosh mutation (1 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:166532 )
N
• mural cell (pericytes and vascular smooth muscle cells) densities are close to normal




Genotype
MGI:4849464
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology
abnormal astrocyte morphology ( J:166532 )
• astrocyte end-feet are mis-localized compared to in wild-type mice

cardiovascular system
abnormal capillary morphology ( J:166532 )
• capillary diameter is increased compared to in wild-type mice
decreased capillary density ( J:166532 )
• capillary density is reduced compared to in wild-type mice
abnormal pericyte morphology ( J:166532 )
• pericyte coverage is less than in wild-type mice but not as severely as in Pdgfbtm3.1Cbet homozygotes
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology




Genotype
MGI:4849466
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability
abnormal astrocyte morphology ( J:166532 )
• astrocyte end-feet are mis-localized compared to in wild-type mice

cardiovascular system
abnormal capillary morphology ( J:166532 )
• capillary diameter is increased compared to in wild-type mice
decreased capillary density ( J:166532 )
• capillary density is reduced compared to in wild-type mice
abnormal pericyte morphology ( J:166532 )
• pericyte coverage is less than in wild-type mice but not as severely as in Pdgfbtm3.1Cbet homozygotes
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory