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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CAG-Sox9,-EGFP)Akis
targeted mutation 1, Andreas Kispert
MGI:4849516
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hprt1tm1(CAG-Sox9,-EGFP)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+ 		involves: 129/Sv * 129S1/SvImJ * NMRI MGI:4849535


Genotype
MGI:4849535
cn1
Allelic
Composition		 Hprt1tm1(CAG-Sox9,-EGFP)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
Genetic
Background		 involves: 129/Sv * 129S1/SvImJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Sox9,-EGFP)Akis mutation (0 available); any Hprt1 mutation (1279 available)
Tbx18tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal ureter morphology ( J:166547 )
• mice exhibit excessive deposition of glycosamiglycans/mucopolysaccharides compared with wild-type mice
• the composition of ureter extracellular matrix is altered compared to in wild-type mice
• however, radial patterning of ureteric mesenchyme is normal
abnormal ureter smooth muscle morphology ( J:166547 )
• mice exhibit disorganized smooth muscle layers in the ureters with round smooth muscle cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory