Phenotypes associated with this allele

• Allele Symbol: Cops5^tm1Fxc
• Allele Name: targeted mutation 1, Francois-Xavier Claret
• Allele ID: MGI:4849637
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cops5^tm1Fxc/Cops5^tm1Fxc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4849640
ht2	Cops5^tm1Fxc/Cops5^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4849641

Genotype
MGI:4849640

hm1

• Allelic Composition: Cops5^tm1Fxc/Cops5^tm1Fxc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:166561 )

• mice die between E6.5 and E7.5

embryo

abnormal inner cell mass apoptosis ( J:166561 )

• increased apoptosis in inner cell mass cultures

increased embryonic tissue cell apoptosis ( J:166561 )

• in embryos at E6.5

decreased inner cell mass proliferation ( J:166561 )

• cultured inner cell mass exhibit reduced proliferation compared with wild-type cells

embryonic growth retardation ( J:166561 )

• at E6.5

decreased embryo size ( J:166561 )

• at E6.5

abnormal egg cylinder morphology ( J:166561 )

• at E6.5 embryos have fewer cells and lack normal architecture and cell differentiation, whereas wild-type controls develop highly structured egg cylinder-stage embryos with a central proamniotic cavity

cellular

abnormal inner cell mass apoptosis ( J:166561 )

• increased apoptosis in inner cell mass cultures

increased embryonic tissue cell apoptosis ( J:166561 )

• in embryos at E6.5

decreased inner cell mass proliferation ( J:166561 )

• cultured inner cell mass exhibit reduced proliferation compared with wild-type cells

abnormal DNA repair ( J:166561 )

• impaired in mouse embryonic fibroblasts

spontaneous chromosome breakage ( J:166561 )

• mouse embryonic fibroblasts exhibit spontaneous DNA break compared with wild-type cells

growth/size/body

embryonic growth retardation ( J:166561 )

• at E6.5

decreased embryo size ( J:166561 )

• at E6.5

homeostasis/metabolism

abnormal DNA repair ( J:166561 )

• impaired in mouse embryonic fibroblasts

Genotype
MGI:4849641

ht2

• Allelic Composition: Cops5^tm1Fxc/Cops5⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

cellular

decreased cell proliferation ( J:166561 )

• in mouse embryonic fibroblasts with fewer cells in S phase