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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc8a1m51207Hubr
mutation 51207, Hubrecht Institute
MGI:4849923
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc8a1m51207Hubr/Slc8a1m51207Hubr involves: C57BL/6 * FVB/N MGI:4867064


Genotype
MGI:4867064
hm1
Allelic
Composition
Slc8a1m51207Hubr/Slc8a1m51207Hubr
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc8a1m51207Hubr mutation (0 available); any Slc8a1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• mice lack a blood-filled vasculature in the yolk sac unlike wild-type mice
• at E9.5 to E10.5, mice exhibit abnormal folding of the heart tube unlike in wild-type mice
• cardiomyocytes derived from E9.5 embryos fibrillate and contract randomly unlike cultured wild-type cells
• calcium ions from cultured cardiomyocytes exhibit smaller amplitude and lower frequency compared with wild-type cells

embryo
• mice lack a blood-filled vasculature in the yolk sac unlike wild-type mice
• at E9.5 to E10.5, branchial arches are dilated compared to in wild-type mice
• at E9.5 to E10.5
• mice lack the hemotrichorial layer unlike in wild-type mice

homeostasis/metabolism
• extreme thoracic edema at E9.5 (J:167034)
• cardiac edema (J:173681)

craniofacial
• at E9.5 to E10.5, branchial arches are dilated compared to in wild-type mice
• at E9.5 to E10.5





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory