reproductive system
|
• rare elongating spermatids are detected in tubules in the testis
• degenerating spermatids and spermatocytes are observed in seminiferous tubules
|
|
• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)
|
|
• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males
|
|
• widespread germ cell apoptosis is observed in testes
|
small testis
(
J:166888
)
|
• reduction in testis size is observed in analyses at 7 months of age
|
|
• more than 80-90% of tubules are arrested at round stage of spermatid differentiation
|
endocrine/exocrine glands
small testis
(
J:166888
)
|
• reduction in testis size is observed in analyses at 7 months of age
|
cellular
|
• rare elongating spermatids are detected in tubules in the testis
• degenerating spermatids and spermatocytes are observed in seminiferous tubules
|
|
• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)
|
|
• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males
|
|
• widespread germ cell apoptosis is observed in testes
|