All Phenotypes Tg(Spo11-cre)D5Mpel MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jam3^tm1Rha/Jam3^tm1.1Chav Tg(Spo11-cre)D5Mpel/0	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5297584
cn2	Nbn^tm1Nus/Nbn^tm2Nus Tg(Spo11-cre)D5Mpel/0	involves: BALB/c * C57BL/6	MGI:5297583

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatid morphology ( J:166888 )

• rare elongating spermatids are detected in tubules in the testis

• degenerating spermatids and spermatocytes are observed in seminiferous tubules

abnormal manchette morphology ( J:166888 )

• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)

decreased male germ cell number ( J:166888 )

• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males

increased male germ cell apoptosis ( J:166888 )

• widespread germ cell apoptosis is observed in testes

small testis ( J:166888 )

• reduction in testis size is observed in analyses at 7 months of age

arrest of spermatogenesis ( J:166888 )

• more than 80-90% of tubules are arrested at round stage of spermatid differentiation

endocrine/exocrine glands

small testis ( J:166888 )

• reduction in testis size is observed in analyses at 7 months of age

cellular

abnormal spermatid morphology ( J:166888 )

• rare elongating spermatids are detected in tubules in the testis

• degenerating spermatids and spermatocytes are observed in seminiferous tubules

abnormal manchette morphology ( J:166888 )

• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)

decreased male germ cell number ( J:166888 )

• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males

increased male germ cell apoptosis ( J:166888 )

• widespread germ cell apoptosis is observed in testes

Allelic Composition	Nbn^tm1Nus/Nbn^tm2Nus Tg(Spo11-cre)D5Mpel/0
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm1Nus mutation (0 available); any Nbn mutation (59 available)
Nbn^tm2Nus mutation (0 available); any Nbn mutation (59 available)
Tg(Spo11-cre)D5Mpel mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:166888 )

N	• in male mutants, no spermatogenic delay or fertility problems are observed

decreased oocyte number ( J:166888 )

• at 5 weeks, about 50% of females show a reduced oocyte number and ovary size

small ovary ( J:166888 )

• at 5 weeks, about 50% of females show a reduced ovary size and oocyte number