Phenotypes associated with this allele

• Allele Symbol: Abl1^tm2.2Goff
• Allele Name: targeted mutation 2.2, Stephen P Goff
• Allele ID: MGI:4850041
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abl1^tm2.2Goff/Abl1^tm2.2Goff	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:4850043

Genotype
MGI:4850043

hm1

• Allelic Composition: Abl1^tm2.2Goff/Abl1^tm2.2Goff
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:166211 )

• partial neonatal lethality

growth/size/body

decreased body size ( J:166211 )

• runting

• smaller at P10 and P21 than their control littermates

nervous system

abnormal cerebellum development ( J:166211 )

• local disruptions of the basement membrane (BM) located between radial glial endfeet and the meninges during embryonic cerebellar development

• breaches in the BM and abnormal Bergmann glial networks during postnatal cerebellar development

• granule cell hypoplasia

abnormal cerebellar foliation ( J:166211 )

• abnormal anterior cerebellar foliation

ectopic cerebellar granule cells ( J:166211 )

• granule cell ectopia

immune system

thymus atrophy ( J:166211 )

• smaller thymus than their control littermates at P21

spleen atrophy ( J:166211 )

• smaller spleen than their control littermates at P21

hematopoietic system

thymus atrophy ( J:166211 )

• smaller thymus than their control littermates at P21

spleen atrophy ( J:166211 )

• smaller spleen than their control littermates at P21

endocrine/exocrine glands

thymus atrophy ( J:166211 )

• smaller thymus than their control littermates at P21