About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3cdtm2.1Tnr
targeted mutation 2.1, Martin Turner
MGI:4850049
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:4850095
cn2
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4850098
cn3
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:4850097


Genotype
MGI:4850095
cn1
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
abnormal humoral immune response ( J:164283 )
• following immunization, the number of NP2-binding antibody forming cells in the bone marrow and spleen is reduced compared to in wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice

hematopoietic system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice




Genotype
MGI:4850098
cn2
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:164283 )
N
• mice exhibit normal germinal center B cell numbers, NP-specific IgG1 titers, and immune memory response after immunization
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice

hematopoietic system
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice




Genotype
MGI:4850097
cn3
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:164283 )
• 7-fold following immunization with NP-KLH
• following immunization with SRBCs (sheep red blood cells)
decreased T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased CD4-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
• slightly in B cell follicles
• significantly in PNA+ IgD- germinal center areas
decreased T follicular helper cell number ( J:164283 )
• following immunization with NP-KLH of SRBCs (sheep red blood cells)
decreased CD8-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased spleen germinal center number ( J:164283 )
• following immunization with NP-KLH, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased spleen germinal center size ( J:164283 )
• following immunization with SRBCs (sheep red blood cells)
abnormal adaptive immunity ( J:164283 )
• following immunization and a later antigen boost, mice exhibit defective immunological memory compared with wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization with NP33-BSA, the NP-specific IgG1 titers are decreased compared to in similarly treated wild-type mice
• following immunization with NP3-BSA, high-affinity NP-specific IgG1 response is severely impaired compared to in similarly treated wild-type mice
• fewer IgG1-secreting antibody forming cells are detected in the spleen and bone marrow compared to in wild-type mice

hematopoietic system
decreased germinal center B cell number ( J:164283 )
• 7-fold following immunization with NP-KLH
• following immunization with SRBCs (sheep red blood cells)
decreased T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased CD4-positive, alpha-beta T cell number ( J:164283 )
• slightly in B cell follicles
• significantly in PNA+ IgD- germinal center areas
• modestly in the spleen without altering lymph node numbers
decreased T follicular helper cell number ( J:164283 )
• following immunization with NP-KLH of SRBCs (sheep red blood cells)
decreased CD8-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased spleen germinal center number ( J:164283 )
• following immunization with NP-KLH, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased spleen germinal center size ( J:164283 )
• following immunization with SRBCs (sheep red blood cells)
decreased IgG1 level ( J:164283 )
• following immunization with NP33-BSA, the NP-specific IgG1 titers are decreased compared to in similarly treated wild-type mice
• following immunization with NP3-BSA, high-affinity NP-specific IgG1 response is severely impaired compared to in similarly treated wild-type mice
• fewer IgG1-secreting antibody forming cells are detected in the spleen and bone marrow compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory