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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zap70m1Btlr
mutation 1, Bruce Beutler
MGI:4867219
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zap70m1Btlr/Zap70m1Btlr involves: C57BL/6J MGI:4867251


Genotype
MGI:4867251
hm1
Allelic
Composition
Zap70m1Btlr/Zap70m1Btlr
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m1Btlr mutation (0 available); any Zap70 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice display normal T-independent IgM responses to haptenated ficoll and serum levels of IgA (J:167119)
• mice exhibit a normal response to NP-Ficoll (J:185495)
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
• severe T cell deficiency
• mice lack a T-dependent immuoglobin G (IgG) response to model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV) unlike wild-type mice
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
• severe T cell deficiency
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory