Analysis Tools
nervous system
| N |
• male mice exhibit normal paired-pulse facilitation and post-tetanic potentiation
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microgliosis
(
J:182051
)
|
• in the hippocampus at 18 months of age in male mice
|
astrocytosis
(
J:182051
)
|
• in the hippocampus at 18 months of age in male mice
|
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• at branch order 3, the number of nodes in male mice is decreased compared to in wild-type cells
• distance between nodes in male mice is decreased compared to in wild-type cells
|
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• over branch orders 1 through 6, 1 through 6 or 4, apical dendrite length is decreased compared to in wild-type cells
|
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• decreased spine density in the apical dendritic arbor
|
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• in male mice
|
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• male mice exhibit smaller field excitatory postsynaptic potentials compared with wild-type mice
|
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• in male mice
|
behavior/neurological
| N |
• mice exhibit normal passive avoidance in a Morris water maze test and depression in a forced swim test
|
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• at 8 months, male mice never attack an intruder male unlike wild-type mice
|
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• at 8 months, male mice spend less time in the center of an open field compared with wild-type mice
|
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• at 8 months, male mice spend less time exploring a novel object compared with wild-type mice
• however, mice exhibit normal total exploration time
|
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• at 8 months, male mice exhibit longer time to learn the rotarod task with shorter latency to fall compared with wild-type mice
• however, female mice exhibit normal motor learning
|
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• at 8 months, male mice exhibit a longer latency to first interaction with an intruder mouse compared with wild-type mice
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pigmentation
|
• in the hippocampus at 8 and 18 months of age in male mice
|
immune system
microgliosis
(
J:182051
)
|
• in the hippocampus at 18 months of age in male mice
|
hematopoietic system
microgliosis
(
J:182051
)
|
• in the hippocampus at 18 months of age in male mice
|
