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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lims2tm1.1Chen
targeted mutation 1.1, Ju Chen
MGI:4867246
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lims2tm1.1Chen/Lims2tm1.1Chen involves: 129S4/SvJae MGI:4867272
cn2
Lims1tm1.1Chen/Lims1tm1.1Chen
Lims2tm1.1Chen/Lims2tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
involves: 129/Sv * C57BL/6 * DBA/2 MGI:4867270


Genotype
MGI:4867272
hm1
Allelic
Composition
Lims2tm1.1Chen/Lims2tm1.1Chen
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lims2tm1.1Chen mutation (0 available); any Lims2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal heart morphology and physiology under normal conditions
• following infarct induction
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice

homeostasis/metabolism
• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice

muscle
• following infarct induction




Genotype
MGI:4867270
cn2
Allelic
Composition
Lims1tm1.1Chen/Lims1tm1.1Chen
Lims2tm1.1Chen/Lims2tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lims1tm1.1Chen mutation (0 available); any Lims1 mutation (53 available)
Lims2tm1.1Chen mutation (0 available); any Lims2 mutation (20 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 4 weeks
• mice die within 4 weeks

cardiovascular system
• mice show abnormalities in pectinate muscles in atrial appendages
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells
• significantly thinner compact myocardium at P1
• at P1, myocardium exhibit widened gaps of intercalated disks with disarrayed sarcomeres and distorted Z lines compared to in wild-type mice
• at P10, membranes of the intercalated disk are highly convoluted and gaps are widened unlike in wild-type mice
• the myocardium exhibits disruption of cell-cell adhesion compared to in wild-type mice
• hearts are abnormally shaped with a bulge at the base of the right ventricle at P20
• hearts are rounder at P1
• mice exhibit disorganized trabeculae that fail to fuse and incorporate into compact myocardium unlike in wild-type mice
• at P20, the ventricular wall exhibits irregular thickness with a thickened right ventricular free wall and thin left ventricular free wall and septum compared to in wild-type mice
• at P20, hearts show fibrosis, esp. in the ventricular septum and within thinned regions of ventricular myocardium
• few cardiomyocytes attack to a plate coated in fibronectin, laminin, and collagen compared with wild-type cells
• progressive, resulting in death

homeostasis/metabolism
• at P20, a large intracardiac thrombus is frequently detected in the left atria
• extensive in the lungs and liver

liver/biliary system

respiratory system

growth/size/body

muscle
• mice show abnormalities in pectinate muscles in atrial appendages
• cultured attached cardiomyocytes are smaller than similarly treated wild-type cells
• significantly thinner compact myocardium at P1
• at P1, myocardium exhibit widened gaps of intercalated disks with disarrayed sarcomeres and distorted Z lines compared to in wild-type mice
• at P10, membranes of the intercalated disk are highly convoluted and gaps are widened unlike in wild-type mice
• the myocardium exhibits disruption of cell-cell adhesion compared to in wild-type mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory