Phenotypes associated with this allele

• Allele Symbol: Rpe65^tvrm148
• Allele Name: translational vision research model 148
• Allele ID: MGI:4867394
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpe65^tvrm148/Rpe65^tvrm148	C57BL/6J-Rpe65^tvrm148/J	MGI:4867833

Genotype
MGI:4867833

hm1

• Allelic Composition: Rpe65^tvrm148/Rpe65^tvrm148
• Genetic Background: C57BL/6J-Rpe65^tvrm148/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor inner segment ( J:166679 )

• at 1 month of age, IS lengths are approximately 50% shorter than controls with no obvious thinning of the ONL

short photoreceptor outer segment ( J:166679 )

• at 1 month of age, OS lengths are approximately 50% shorter than controls with no obvious thinning of the ONL

retina photoreceptor degeneration ( J:166679 )

• photoreceptors degenerated progressively in homozygous mutant mice from 1 month to 1 year of age, the latest time point examined

• photoreceptor nuclei were reduced in thickness by ~20% at 4 months and ~60% by 1 year of age

abnormal retina pigmentation ( J:166679 )

• patches of depigmentation that is readily discernable by indirect ophthalmoscopy at 5 months of age

retina spots ( J:166679 )

• late onset retinal spotting

abnormal cone electrophysiology ( J:166679 )

• cone b-wave ERGs were comparable to controls at 4 weeks of age but by 17 weeks, the amplitudes were reduced compared to controls

abnormal rod electrophysiology ( J:166679 )

• severely impaired rod ERGs; rod responses were absent by 4 weeks of age

pigmentation

abnormal retina pigmentation ( J:166679 )

• patches of depigmentation that is readily discernable by indirect ophthalmoscopy at 5 months of age

nervous system

short photoreceptor inner segment ( J:166679 )

• at 1 month of age, IS lengths are approximately 50% shorter than controls with no obvious thinning of the ONL

short photoreceptor outer segment ( J:166679 )

• at 1 month of age, OS lengths are approximately 50% shorter than controls with no obvious thinning of the ONL

retina photoreceptor degeneration ( J:166679 )

• photoreceptors degenerated progressively in homozygous mutant mice from 1 month to 1 year of age, the latest time point examined

• photoreceptor nuclei were reduced in thickness by ~20% at 4 months and ~60% by 1 year of age