Phenotypes associated with this allele

• Allele Symbol: Crx^tvrm65
• Allele Name: translational vision research model 65
• Allele ID: MGI:4867395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crx^tvrm65/Crx^tvrm65	C57BL/6J-Crx^tvrm65/J	MGI:4867740

Genotype
MGI:4867740

hm1

• Allelic Composition: Crx^tvrm65/Crx^tvrm65
• Genetic Background: C57BL/6J-Crx^tvrm65/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal ocular fundus morphology ( J:166679 )

• pan-retinal, grainy fundus appearance

absent photoreceptor inner segment ( J:166679 )

• at P14 and P21, inner segments (ISs) are rarely observed; absent at three months of age

absent photoreceptor outer segment ( J:166679 )

• at P14, P21 and three months of age, OSs are absent

retina photoreceptor degeneration ( J:166679 )

• by P21, photoreceptor cell bodies are reduced to ~60% of controls

abnormal retina pigmentation ( J:166679 )

• with age, patches of depigmentation within the central retina are seen

retina outer nuclear layer degeneration ( J:166679 )

• at three months of age, only 2-3 layers of outer nuclear layer (ONL) remained

thin retina outer plexiform layer ( J:166679 )

• at P21, the outer plexiform layer (OPL) is thinner, approximately 40% of controls

nervous system

absent photoreceptor inner segment ( J:166679 )

• at P14 and P21, inner segments (ISs) are rarely observed; absent at three months of age

absent photoreceptor outer segment ( J:166679 )

• at P14, P21 and three months of age, OSs are absent

retina photoreceptor degeneration ( J:166679 )

• by P21, photoreceptor cell bodies are reduced to ~60% of controls

pigmentation

abnormal retina pigmentation ( J:166679 )

• with age, patches of depigmentation within the central retina are seen