Analysis Tools
mortality/aging
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• most mice die prior to 1 months of age with remaining mice dying within one year
• however, supplementing drinking water with glucose improves survival
|
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• mice exhibit kyphosis, reduced bone density, and increased staining for cellular senescence (increased staining for acidic beta-galactosidase) compared with wild-type mice
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reproductive system
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• only 6 of 12 female mice produce litters when mated to wild-type males
|
 |
• male mice cannot impregnate wild-type females unlike wild-type males
• however, sperm is capable of fertilizing eggs normally in vitro
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homeostasis/metabolism
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• insulin-stimulated glucose uptake in increased in the quadriceps, white adipose tissue, spleen, liver, thymus, and lung compared to in wild-type mice
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• throughout nursing
• however, supplementing drinking water with glucose improves circulating glucose levels
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hypoglycemia
(
J:167023
)
|
• as early as P3
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skeleton
malocclusion
(
J:167023
)
growth/size/body
malocclusion
(
J:167023
)
|
• at P15 and onward
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• starting at P3
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adipose tissue
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• as animals live (visceral and subcutaneous)
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vision/eye
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• with discharge and not fully open eyes
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immune system
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• glucose uptake in the spleen is greater than in wild-type mice
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behavior/neurological
|
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• mice cannot nurse their young unlike wild-type mice
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craniofacial
malocclusion
(
J:167023
)
cellular
|
• mice exhibit increased staining for acidic beta-galactosidase compared with wild-type mice
|
integument
