Phenotypes associated with this allele

• Allele Symbol: B3gnt5^tm2.1Big
• Allele Name: targeted mutation 2.1, Darell D Bigner
• Allele ID: MGI:4867403
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B3gnt5^tm2.1Big/B3gnt5^tm2.1Big	involves: 129/Sv * C57BL/6 * FVB/N	MGI:4867407
ht2	B3gnt5^tm2.1Big/B3gnt5^+	involves: 129/Sv * C57BL/6 * FVB/N	MGI:4867408

Genotype
MGI:4867407

hm1

• Allelic Composition: B3gnt5^tm2.1Big/B3gnt5^tm2.1Big
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:166763 )

premature death ( J:166763 )

• an increasing number of mutant mice die between 5-15 months of age

pregnancy-related premature death ( J:166763 )

• some dams die during delivery

neonatal lethality, incomplete penetrance ( J:166763 )

• some die immediately after birth

reproductive system

decreased litter size ( J:166763 )

• in homozygous x homozygous matings

immune system

decreased B cell number ( J:166763 )

• decrease in the number of CD19+ B cells in the spleen

abnormal spleen morphology ( J:166763 )

enlarged spleen ( J:166763 )

intermingled spleen red and white pulp ( J:166763 )

• the limits between the germinal center and red pulp are blurred

abnormal spleen germinal center morphology ( J:166763 )

• in some splenic nodules the germinal center architecture is disturbed or the germinal center is missing

absent spleen marginal zone ( J:166763 )

increased spleen white pulp amount ( J:166763 )

enlarged lymph nodes ( J:166763 )

growth/size/body

obese ( J:166763 )

• age related obesity is seen in some males at about 5 months of age

enlarged spleen ( J:166763 )

hematopoietic system

decreased B cell number ( J:166763 )

• decrease in the number of CD19+ B cells in the spleen

abnormal spleen morphology ( J:166763 )

enlarged spleen ( J:166763 )

intermingled spleen red and white pulp ( J:166763 )

• the limits between the germinal center and red pulp are blurred

abnormal spleen germinal center morphology ( J:166763 )

• in some splenic nodules the germinal center architecture is disturbed or the germinal center is missing

absent spleen marginal zone ( J:166763 )

increased spleen white pulp amount ( J:166763 )

Genotype
MGI:4867408

ht2

• Allelic Composition: B3gnt5^tm2.1Big/B3gnt5⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

mortality/aging

pregnancy-related premature death ( J:166763 )

• some dams die during delivery

reproductive system

reduced fertility ( J:166763 )

• lower pregnancy rate than expected in heterozygous x heterozygous matings

• some heterozygous pairs lose fertility after the first mating

decreased litter size ( J:166763 )

• in heterozygous x heterozygous matings

growth/size/body

obese ( J:166763 )

• age related obesity is seen in some males at about 5 months of age