Phenotypes associated with this allele

• Allele Symbol: Nlgn3^tm1.1Htz
• Allele Name: targeted mutation 1.1, Nathaniel Heintz
• Allele ID: MGI:4867464
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlgn3^tm1.1Htz/Nlgn3^tm1.1Htz	involves: C57BL/6 * FVB/N	MGI:4867504
ot2	Nlgn3^tm1.1Htz/Y	involves: C57BL/6 * FVB/N	MGI:4867503

Genotype
MGI:4867504

hm1

• Allelic Composition: Nlgn3^tm1.1Htz/Nlgn3^tm1.1Htz
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:167116 )

♀ • shorter latency to return to nest area than control females at 9 days of age

abnormal spatial learning ( J:167116 )

♀ • during "reversal", equivalent amounts of time spent in the new platform quadrant and the old platform quadrant whereas controls spend more time in the old platform quadrant

increased thigmotaxis ( J:167116 )

♀ • on the first day of training in a Morris water maze

abnormal righting response ( J:167116 )

♀ • slower to develop

growth/size/body

postnatal growth retardation ( J:167116 )

♀ • slower growth rate

Genotype
MGI:4867503

ot2

• Allelic Composition: Nlgn3^tm1.1Htz/Y
• Genetic Background: involves: C57BL/6 * FVB/N

behavior/neurological

abnormal spatial learning ( J:167116 )

♂ • during "reversal", equivalent amounts of time spent in the new platform quadrant and the old platform quadrant whereas controls spend more time in the old platform quadrant

increased thigmotaxis ( J:167116 )

♂ • on the first day of training in a Morris water maze

decreased startle reflex ( J:167116 )

♂ • less startle response to sudden loud noise

♂ • minimal startle threshold similar to control males

abnormal motor coordination/balance ( J:167116 )

♂

abnormal righting response ( J:167116 )

♂ • slower to develop

enhanced coordination ( J:167116 )

♂ • improved rotarod performance compared to controls but only in males

impaired coordination ( J:167116 )

♂ • wire hanging duration is shorter than control males

decreased vertical activity ( J:167116 )

♂ • reduced upright rearing in open field tests

decreased vocalization ( J:167116 )

♂ • less ultrasonic vocalizations on post natal day 8 than for control males

nervous system

nervous system phenotype ( J:167116 )

♂N • prepulse inhibition is normal

growth/size/body

increased growth rate ( J:167116 )

♂