Phenotypes associated with this allele

• Allele Symbol: Mesp2^{tm17.1(VP16/Rbpj)Ysa}
• Allele Name: targeted mutation 17.1, Yumiko Saga
• Allele ID: MGI:4867476
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm17.1(VP16/Rbpj)Ysa/Mesp2^tm17.1(VP16/Rbpj)Ysa	involves: C57BL/6 * CBA	MGI:4867478
ht2	Mesp2^tm17.1(VP16/Rbpj)Ysa/Mesp2^+	involves: C57BL/6 * CBA	MGI:4867479
ht3	Mesp2^tm13.1(cre/Esr1*)Ysa/Mesp2^tm17.1(VP16/Rbpj)Ysa	involves: C57BL/6 * CBA	MGI:4867480

Genotype
MGI:4867478

hm1

• Allelic Composition: Mesp2^{tm17.1(VP16/Rbpj)Ysa}/Mesp2^{tm17.1(VP16/Rbpj)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal vertebrae morphology ( J:167045 )

• vertebrae are completely caudalized

vertebral fusion ( J:167045 )

• severe

embryo

abnormal rostral-caudal patterning of the somites ( J:167045 )

• expression analysis indicates impaired rostral-caudal patterning

Genotype
MGI:4867479

ht2

• Allelic Composition: Mesp2^{tm17.1(VP16/Rbpj)Ysa}/Mesp2⁺
• Genetic Background: involves: C57BL/6 * CBA

skeleton

skeleton phenotype ( J:167045 )

N • despite expressing a constitutively active form of Rbpj, no abnormalities are detected

Genotype
MGI:4867480

ht3

• Allelic Composition: Mesp2^{tm13.1(cre/Esr1*)Ysa}/Mesp2^{tm17.1(VP16/Rbpj)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

skeleton

fusion of vertebral arches ( J:167045 )

• the pedicles of the neural arches fuse with their neighbors

• the degree of fusion is increased compared to mice homozygous for Mesp2 ^{tm13.1(cre/Esr1*)Ysa}