Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-ELN*)60Zu
• Allele Name: transgene insertion 60, Zsolt Urban
• Allele ID: MGI:4867517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-ELN*)60Zu/0	C57BL/6J-Tg(CAG-ELN*)60Zu	MGI:4867519

Genotype
MGI:4867519

tg1

• Allelic Composition: Tg(CAG-ELN*)60Zu/0
• Genetic Background: C57BL/6J-Tg(CAG-ELN*)60Zu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:166809 )

• apoptosis in the lungs is elevated

overexpanded pulmonary alveolus ( J:166809 )

abnormal respiratory mechanics ( J:166809 )

• lung elastic recoil pressure is reduced

• elastic modulus (stiffness) of lung tissue is decreased

increased lung compliance ( J:166809 )

• at all lung volumes, lungs have greater compliance than non-transgenic mice

cardiovascular system

abnormal aorta elastic fiber morphology ( J:166809 )

• mutant elastin is not incorporated into the elastic fibers of the aorta

integument

abnormal cutaneous elastic fiber morphology ( J:166809 )

• mutant elastin is not incorporated into the elastic fibers of the skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cutis laxa		DOID:3144	OMIM:PS123700	J:166809