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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja10tm2.1(cre)Kwi
targeted mutation 2.1, Klaus Willecke
MGI:4867556
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gja10tm2.1(cre)Kwi/Gja10+
Gria4tm1Mony/Gria4tm1Mony 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5558942


Genotype
MGI:5558942
cn1
Allelic
Composition		 Gja10tm2.1(cre)Kwi/Gja10+
Gria4tm1Mony/Gria4tm1Mony
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja10tm2.1(cre)Kwi mutation (0 available); any Gja10 mutation (24 available)
Gria4tm1Mony mutation (0 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:207456 )
• retinal horizontal cells show significantly smaller glutamate- or AMPA-induced inward currents than controls

nervous system
abnormal glutamate-mediated receptor currents ( J:207456 )
• somas of horizontal cells show significantly smaller glutamate- or AMPA-induced inward currents (by about 75%) compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory