Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fbxw7tm1.1Axbe targeted mutation 1.1, Axel Behrens MGI:4867641 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number of Map+ cells that differentiate in culture is increased while the number of Nes+ cells is decreased compared to in cultures from wild-type mice
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• the number of Map+ cells that differentiate in culture is increased while the number of Nes+ cells is decreased compared to in cultures from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued
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• supranumeral fissures
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• partially rescued compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice
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• the cellularity defect in the mantle layer of the midbrain tectum observed in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice is rescued
• the number of stem cells in the tectal ventricular zone is increased compared to in wild-type mice
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• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal gliogenesis
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• the number of neuroblasts in the cortex is reduced compared to in wild-type mice
• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice
• neurosphere apoptosis is increased compared to in wild-type mice
• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells
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• mice exhibit a reduction in the number of cells in regions of the brain occupied by committed progenitors and differentiated cells compared with wild-type mice
• areas containing immature cells exhibit normal or increased numbers of cells compared to in wild-type mice
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• the intermediate zone contains fewer cells than in wild-type mice
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• the cortical plate contains fewer cells than in wild-type mice
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• the cerebellar anlage contains fewer cells than in wild-type mice
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• the midbrain tectum, especially the tectal mantle, contains fewer cells than in wild-type mice
• the number of cells in the tectal ventricular zone is increased compared to in wild-type mice
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• the thalamus contains fewer cells than in wild-type mice
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• the forebrain cortex contains fewer cells than in wild-type mice
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• the cortical subventricular zone contains fewer cells than in wild-type mice
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• smaller and fewer without a defect in proliferation
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• the number of neuroblasts in the cortex is reduced compared to in wild-type mice
• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice
• neurosphere apoptosis is increased compared to in wild-type mice
• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• molecular layer structure is normal
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• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice
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• Purkinje cells are small, irregularly-shaped, less organized, more widely spread, and defective in arborization compared to in wild-type mice
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• between P2, P7 and in the adult
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• supranumeral fissures in the central lobes
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• as early as P2
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• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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