Phenotypes associated with this allele

• Allele Symbol: Rest^tm1.1Whk
• Allele Name: targeted mutation 1.1, William H Klein
• Allele ID: MGI:4867679
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rest^tm1.1Whk/Rest^tm1.1Whk Tg(Six3-cre)69Frty/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:4867680
cn2	Atoh7^tm2Gan/Atoh7^tm2Gan Rest^tm1.1Whk/Rest^tm1.1Whk Tg(Six3-cre)69Frty/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:4867681

Genotype
MGI:4867680

cn1

• Allelic Composition: Rest^tm1.1Whk/Rest^tm1.1Whk; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina progenitor cell morphology ( J:167071 )

• increase in the number of mitotic retinal progenitor cells compared to littermate controls

abnormal retina ganglion layer morphology ( J:167071 )

• many cell clumps protrude towards the retinal pigment epithelia

increased retina ganglion cell number ( J:167071 )

• at E14, E15.5 and P20

thick retina ganglion layer ( J:167071 )

• at P20

thick retina inner plexiform layer ( J:167071 )

• thicker at P20

nervous system

increased retina ganglion cell number ( J:167071 )

• at E14, E15.5 and P20

Genotype
MGI:4867681

cn2

• Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan; Rest^tm1.1Whk/Rest^tm1.1Whk; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

vision/eye

abnormal retina morphology ( J:167071 )

• mis-patterning of the retina is more severe than in mutant mice wild-type for Atoh7

abnormal retina development ( J:167071 )

• few ganglion cells are detected in the nascent retinal ganglion layer at E13.5 despite many being generated in the neuroblast layer suggesting a defect in migration and maturation

• many dying cells are present in the retinal ganglion cell layer at E13.5