Analysis Tools
mortality/aging
|
• partial lethality between E10.5 and E12.5
• mice that survive are viable and fertile
|
cardiovascular system
|
• decreased and poorly organized at E11.5
|
|
• at E11.5
|
|
• poorly formed at E11.5
|
|
• frequently seen at E11.5
|
|
• in about 50% of embryos at E10.5
|
|
• decrease in the number of proliferation myocytes in the heart at E10
|
growth/size/body
|
• about 50% of embryos show some developmental delay at E10.5
|
|
• in males at 3 months of age
|
|
• evident in surviving mice by 1 week of age
|
muscle
|
• decreased and poorly organized at E11.5
|
|
• at E11.5
|
|
• in the calf probably as a result of fewer myofibers as the size of individual fibers and number of fibers per cross-sectional area are similar to wild-type controls
|
|
• increased death of cultured satellite cells over a 96 h period
• however, no difference in satellite cell proliferation is detected
|
|
• decrease in the number of proliferation myocytes in the heart at E10
|
|
• impaired regeneration in calf muscles following cardiotoxin induced necrotic damage
|
embryo
|
• about 50% of embryos show some developmental delay at E10.5
|
homeostasis/metabolism
|
• frequently seen at E11.5
|
|
• in about 50% of embryos at E10.5
|
cellular
|
• decrease in the number of proliferation myocytes in the heart at E10
|
