Phenotypes associated with this allele

• Allele Symbol: Tsku^tm1Koth
• Allele Name: targeted mutation 1, Kunimasa Ohta
• Allele ID: MGI:4867728
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsku^tm1Koth/Tsku^tm1Koth	B6.Cg-Tsku^tm1Koth	MGI:4867729

Genotype
MGI:4867729

hm1

• Allelic Composition: Tsku^tm1Koth/Tsku^tm1Koth
• Genetic Background: B6.Cg-Tsku^tm1Koth

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enlarged lateral ventricles ( J:166597 )

abnormal corpus callosum morphology ( J:166597 )

• axonal bundles in the corpus callosum are thinner than in wild-type mice

abnormal anterior commissure morphology ( J:166597 )

• the axons of the anterior and posterior portion of the anterior commissure (aAC and pAC) are extremely thin compared to in wild-type mice

• the aAC axons are 5 times thinner than in wild-type mice

• no thick anterior commissure extend from the ventral to dorsal area unlike in wild-type mice

• at P0, anterior commissure axons are thin and do not cross the midline unlike in wild-type mice

• the aAC and pAC fails to cross the midline unlike in wild-type mice

• however, anterior commissure axon bundles are of normal thickness at P10