All Phenotypes Prkd2<tm1.1Daca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkd2^tm1.1Daca
targeted mutation 1.1, Doreen A Cantrell
MGI:4867730

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkd2^tm1.1Daca/Prkd2^tm1.1Daca	involves: C57BL/6	MGI:4867737

Allelic Composition	Prkd2^tm1.1Daca/Prkd2^tm1.1Daca
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2^tm1.1Daca mutation (1 available); any Prkd2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:166867 )

N	• mice exhibit normal development of mature T-lymphocytes • basal immunoglobulin serum levels are normal

decreased IgG1 level ( J:166867 )

• mice exhibit a reduced antigen-specific IgG1 response compared with wild-type mice

decreased IgM level ( J:166867 )

• mice exhibit a reduced antigen-specific IgM response compared with wild-type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:166867 )

• CD4+ T cells stimulated in vitro via TCR produce less IL2 and IFN-gamma than similarly treated wild-type cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:166867 )

• CD8+ T cells stimulated in vitro via TCR produce less IL2 and IFN-gamma than similarly treated wild-type cells

decreased interferon-gamma secretion ( J:166867 )

• CD4+ and CD8+ T cells stimulated in vitro via TCR produce less IFN-gamma than similarly treated wild-type cells

decreased interleukin-2 secretion ( J:166867 )

• CD4+ and CD8+ T cells stimulated in vitro via TCR produce less IL2 than similarly treated wild-type cells

hematopoietic system

decreased IgG1 level ( J:166867 )

• mice exhibit a reduced antigen-specific IgG1 response compared with wild-type mice

decreased IgM level ( J:166867 )

• mice exhibit a reduced antigen-specific IgM response compared with wild-type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:166867 )

• CD4+ T cells stimulated in vitro via TCR produce less IL2 and IFN-gamma than similarly treated wild-type cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:166867 )

• CD8+ T cells stimulated in vitro via TCR produce less IL2 and IFN-gamma than similarly treated wild-type cells

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