Phenotypes associated with this allele

• Allele Symbol: Spdef^tm1Shiv
• Allele Name: targeted mutation 1, Ramesh Shivdasani
• Allele ID: MGI:4867866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spdef^tm1Shiv/Spdef^tm1Shiv	involves: 129S4/SvJae	MGI:4867867

Genotype
MGI:4867867

hm1

• Allelic Composition: Spdef^tm1Shiv/Spdef^tm1Shiv
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Polypoid antral hyperplasia in Spdef^tm1Shiv/Spdef^tm1Shiv mice

mortality/aging

prenatal lethality, incomplete penetrance ( J:166876 )

• viable at birth but born in slightly reduced numbers

digestive/alimentary system

abnormal stomach pyloric antrum morphology ( J:166876 )

• profound thickening of the antral stomach at 4 months of age or older

• 50% of mice develop polypoid hyperplasia of the antrum within 1.5 years of life

abnormal stomach mucosa morphology ( J:166876 )

• antral secretory granules are reduced in mucous gland cells

abnormal stomach glandular epithelium morphology ( J:166876 )

• expanded zone of proliferating epithelial cells

• dilated, elongated, and tortuous foveolae

abnormal digestive system physiology ( J:166876 )

small intestinal inflammation ( J:166876 )

• leukocyte infiltrates sometimes seen in the duodenal submucosa

stomach inflammation ( J:166876 )

• moderate to severe antral inflammation in 90% of mice by 4 months of age

• inflammation always present when antral hyperplasia is present

• formation of submucosal lymphoid follicles sometimes in older animals

• inflammation usually absent in gastric corpus when antral hyperplasia is absent

immune system

small intestinal inflammation ( J:166876 )

• leukocyte infiltrates sometimes seen in the duodenal submucosa

stomach inflammation ( J:166876 )

• moderate to severe antral inflammation in 90% of mice by 4 months of age

• inflammation always present when antral hyperplasia is present

• formation of submucosal lymphoid follicles sometimes in older animals

• inflammation usually absent in gastric corpus when antral hyperplasia is absent