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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm1tvrm27
translational vision research model 27
MGI:4867880
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm1tvrm27/Trpm1tvrm27 involves: C57BL/6J MGI:5568983
ht2
 		Trpm1tvrm27/Trpm1+ involves: C57BL/6J MGI:5568987
ht3
 		Trpm1tm1Lex/Trpm1tvrm27 involves: 129S/SvEvBrd * C57BL/6J MGI:5568986


Genotype
MGI:5568983
hm1
Allelic
Composition		 Trpm1tvrm27/Trpm1tvrm27
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm1tvrm27 mutation (1 available); any Trpm1 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:209941 )
N
• mice exhibit normal retinal anatomy
abnormal rod electrophysiology ( J:209941 )
• no b-wave in dark-adapted mice
• however, a-wave is present

nervous system




Genotype
MGI:5568987
ht2
Allelic
Composition		 Trpm1tvrm27/Trpm1+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm1tvrm27 mutation (1 available); any Trpm1 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal channel response ( J:209941 )
• in whole cell recordings, depolarizing bipolar cells exhibit reduced response to LY341495 and capsaicin compared with wild-type cells

vision/eye
abnormal rod electrophysiology ( J:209941 )
• reduced b-wave in dark-adapted mice




Genotype
MGI:5568986
ht3
Allelic
Composition		 Trpm1tm1Lex/Trpm1tvrm27
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm1tm1Lex mutation (2 available); any Trpm1 mutation (101 available)
Trpm1tvrm27 mutation (1 available); any Trpm1 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal rod electrophysiology ( J:209941 )
• no b-wave in dark-adapted mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory