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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Anp32etm1Mak
targeted mutation 1, Tak Mak
MGI:4867888
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Anp32etm1Mak/Anp32etm1Mak involves: 129P2/OlaHsd * C57BL/6 MGI:4867890
cn2
 		Anp32etm1Mak/Anp32etm1Mak
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129 * C3H * C57BL/6 MGI:7711577
cx3
 		Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003066
cx4
 		Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003067
cx5
 		Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32e+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003068
cx6
 		Anp32atm1Mak/Anp32a+
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003069
cx7
 		Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32b+
Anp32etm1Mak/Anp32etm1Mak 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003070
cx8
 		Anp32atm1Mak/Anp32a+
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32e+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5003071
cx9
 		Anp32atm1Mak/Anp32atm1Mak
Anp32etm1Mak/Anp32etm1Mak 		involves: 129P2/OlaHsd * C57BL/6 MGI:4867891


Genotype
MGI:4867890
hm1
Allelic
Composition		 Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:166683 )
• mice exhibit are viable and fertile with no specific pathologies




Genotype
MGI:7711577
cn2
Allelic
Composition		 Anp32etm1Mak/Anp32etm1Mak
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129 * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
Cfdp1tm1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
Cfdp1tm2.1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal intracellular organelle physiology ( J:349245 )
N
• H2A.Z and RCC1 levels at the major satellite repeats are increased in rescue mice relative to both conditional mutant mice wild-type for Anp32e and wild-type controls

craniofacial
craniofacial phenotype ( J:349245 )
N
• loss of Anp32e expression largely rescues the craniofacial phenotype seen in conditional mutant mice wild-type for Anp32e
• maxilla and mandible are mineralized unlike in conditional mutant mice wild-type for Anp32e




Genotype
MGI:5003066
cx3
Allelic
Composition		 Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:172042 )
• very few mice survive to weaning




Genotype
MGI:5003067
cx4
Allelic
Composition		 Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:172042 )
• no mice survive to weaning




Genotype
MGI:5003068
cx5
Allelic
Composition		 Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32e+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:172042 )
• no mice survive to weaning




Genotype
MGI:5003069
cx6
Allelic
Composition		 Anp32atm1Mak/Anp32a+
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:172042 )
• no mice survive to weaning




Genotype
MGI:5003070
cx7
Allelic
Composition		 Anp32atm1Mak/Anp32atm1Mak
Anp32btm1Mak/Anp32b+
Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:172042 )
N
• expected number of mice survive to weaning




Genotype
MGI:5003071
cx8
Allelic
Composition		 Anp32atm1Mak/Anp32a+
Anp32btm1Mak/Anp32btm1Mak
Anp32etm1Mak/Anp32e+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32btm1Mak mutation (1 available); any Anp32b mutation (102 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:172042 )
• no mice survive to weaning




Genotype
MGI:4867891
cx9
Allelic
Composition		 Anp32atm1Mak/Anp32atm1Mak
Anp32etm1Mak/Anp32etm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32atm1Mak mutation (1 available); any Anp32a mutation (57 available)
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:166683 )
N
• mice exhibit normal viability

reproductive system
reproductive system phenotype ( J:166683 )
N
• mice exhibit normal fertility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory