Phenotypes associated with this allele

• Allele Symbol: Dtymk^tm1(KOMP)Mbp
• Allele Name: targeted mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:4867962
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dtymk^tm1(KOMP)Mbp/Dtymk^tm1(KOMP)Mbp	C57BL/6-Dtymk^tm1(KOMP)Mbp	MGI:7628477
ht2	Dtymk^tm1(KOMP)Mbp/Dtymk^+	C57BL/6-Dtymk^tm1(KOMP)Mbp	MGI:7628478

Genotype
MGI:7628477

hm1

• Allelic Composition: Dtymk^tm1(KOMP)Mbp/Dtymk^tm1(KOMP)Mbp
• Genetic Background: C57BL/6-Dtymk^tm1(KOMP)Mbp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:347587 )

• embryonic lethality before E12.5

• supplementation of heterozygous breeding pairs with deoxyuridine (AIN93G diet) does not rescue the embryonic lethality of homozygotes

• heterozygous dams maintained on a control, folic acid deficient, or excess folic acid diet prior to mating with heterozygous males, show no differences in the average litter size and the average number of resorptions per litter among the different diets, indicating no effect of these diets on survival of homozygotes

Genotype
MGI:7628478

ht2

• Allelic Composition: Dtymk^tm1(KOMP)Mbp/Dtymk⁺
• Genetic Background: C57BL/6-Dtymk^tm1(KOMP)Mbp

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:347587 )

• expression of deoxythymidylate kinase (dTYMK) is decreased by about 3-fold in embryos

nervous system

nervous system phenotype ( J:347587 )

N • mice from dams fed a control, folic acid deficient, or excess folic acid diet do not show the presence of open neural tube defects, spina bifida, or exencephaly