Analysis Tools
mortality/aging
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• fewer than expected mice are present at weaning
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• fewer than expected mice are present between E12.5 and E18.5
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cardiovascular system
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• mice with bleeding exhibit dilated ventral skin blood vessels with poor mural cell coverage compared with wild-type mice
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• mice with bleeding exhibit dilated ventral skin blood vessels with poor mural cell coverage compared with wild-type mice
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• mice with bleeding exhibit dilated ventral skin blood vessels with poor mural cell coverage compared with wild-type mice
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• in some mice
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hemorrhage
(
J:167262
)
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• at E14.5, some mice exhibit subcutaneous hemorrhage unlike wild-type mice
• at E18.5, some mice exhibit hemorrhage in the neck, head, limbs, and other areas of the body unlike wild-type mice
• at E18.5, some mice exhibit hemorrhagic lesions in pericardial cavities, periocular tissues, salivary glands, and subcutaneous tissues unlike wild-type mice
• however, blood coagulation is normal
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• at E18.5, 4 of 17 mice exhibit thymic hemorrhage unlike wild-type mice
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• in 14 of 17 mice at E18.5
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• in 1 of 17 mice at E18.5
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growth/size/body
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• some mice at E10.5 and E12.5
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omphalocele
(
J:167262
)
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• in some mice at E18.5
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• some mice at E14.5
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embryo
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• at E12.5, one third of mice exhibit various developmental anomalies unlike wild-type mice
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• some mice at E10.5 and E12.5
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craniofacial
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• in some mice at E18.5
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skeleton
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• in some mice at E18.5
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homeostasis/metabolism
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• some mice exhibit effusions in the body surface unlike wild-type mice
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• in some mice
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• in 14 of 17 mice at E18.5
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skin edema
(
J:167262
)
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• in some mice at E14.5 and E18.5
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immune system
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• lymph sacs and lymphatic vessels are dilated compared to in wild-type mice
• however, lymphatic endothelial cell proliferation is normal
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integument
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• mice with bleeding exhibit dilated ventral skin blood vessels with poor mural cell coverage compared with wild-type mice
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skin edema
(
J:167262
)
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• in some mice at E14.5 and E18.5
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muscle
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• mice with bleeding exhibit dilated ventral skin blood vessels with poor mural cell coverage compared with wild-type mice
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respiratory system
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• in 1 of 17 mice at E18.5
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