Phenotypes associated with this allele

• Allele Symbol: Mirc19^tm1.1Kcho
• Allele Name: targeted mutation 1.1, Kamal Chowdhury
• Allele ID: MGI:4868242
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc19^tm1.1Kcho/Mirc19^tm1.1Kcho	B6.129-Mirc19^tm1.1Kcho	MGI:4868377

Genotype
MGI:4868377

hm1

• Allelic Composition: Mirc19^tm1.1Kcho/Mirc19^tm1.1Kcho
• Genetic Background: B6.129-Mirc19^tm1.1Kcho

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:166674 )

♀N • despite the lack of terminal end buds in mammary gland ducts, ductal outgrowth is retained

cellular

maternal effect ( J:166674 )

♀ • pups born to or nursed by female mice die within 5 days of birth

♀ • however, female mice exhibit normal nursing behavior

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166674 )

♀N • mice exhibit normal circulating estradiol and growth hormone levels

integument

abnormal mammary gland growth during lactation ( J:166674 )

♀ • mammary glands exhibit dense lobuloalveolar structures that are restricted to the region close to the nipple area without any epithelial structures in the rest of the fat pad compared to in wild-type mice

abnormal mammary gland duct morphology ( J:166674 )

♀ • ducts lack terminal end buds unlike in wild-type mice

♀ • proximal and relatively distal ducts lack collagen-rich periductal stroma unlike in wild-type mice

abnormal mammary gland alveolus morphology ( J:166674 )

♀ • at 5, 10, and 40 weeks of age, the rudimental ductal tree gland fails to initiate ductal outgrowth and do not produce terminal end buds compared to in wild-type mice

♀ • lobualveolar structures fail to extend far into the fat pad unlike in wild-type mice

abnormal mammary gland stroma morphology ( J:166674 )

♀ • proximal and relatively distal ducts lack collagen-rich periductal stroma unlike in wild-type mice

hypolactation ( J:166674 )

♀ • milk production is decreased compared to in wild-type mice

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:166674 )

♀ • mammary glands exhibit dense lobuloalveolar structures that are restricted to the region close to the nipple area without any epithelial structures in the rest of the fat pad compared to in wild-type mice

abnormal mammary gland duct morphology ( J:166674 )

♀ • ducts lack terminal end buds unlike in wild-type mice

♀ • proximal and relatively distal ducts lack collagen-rich periductal stroma unlike in wild-type mice

abnormal mammary gland alveolus morphology ( J:166674 )

♀ • at 5, 10, and 40 weeks of age, the rudimental ductal tree gland fails to initiate ductal outgrowth and do not produce terminal end buds compared to in wild-type mice

♀ • lobualveolar structures fail to extend far into the fat pad unlike in wild-type mice

abnormal mammary gland stroma morphology ( J:166674 )

♀ • proximal and relatively distal ducts lack collagen-rich periductal stroma unlike in wild-type mice

hypolactation ( J:166674 )

♀ • milk production is decreased compared to in wild-type mice