Phenotypes associated with this allele

• Allele Symbol: Mmp15^tm1Kohl
• Allele Name: targeted mutation 1, Kenn Holmbeck
• Allele ID: MGI:4868411
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp15^tm1Kohl/Mmp15^tm1Kohl	involves: 129S6/SvEvTac	MGI:4868428
cn2	Mmp14^tm1Hbh/Mmp14^tm1.1Khol Mmp15^tm1Kohl/Mmp15^tm1Kohl Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	MGI:4868430
cx3	Mmp14^tm1Hbh/Mmp14^tm1Hbh Mmp15^tm1Kohl/Mmp15^tm1Kohl	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4868429

Genotype
MGI:4868428

hm1

• Allelic Composition: Mmp15^tm1Kohl/Mmp15^tm1Kohl
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:167396 )

• mice exhibit normal lifespan, behavior, grooming habits, reproduction, and litter rearing

Genotype
MGI:4868430

cn2

• Allelic Composition: Mmp14^tm1Hbh/Mmp14^tm1.1Khol; Mmp15^tm1Kohl/Mmp15^tm1Kohl; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

embryo

abnormal placental labyrinth vasculature morphology ( J:167396 )

• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice

absent placental labyrinth ( J:167396 )

• at E12.5 in tamoxifen-treated mice starting at E7.5

• however, placenta develops normally in mice treated with tamoxifen at E12.5

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:167396 )

N • tamoxifen-treated mice exhibit normal mammary gland involution

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:167396 )

• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice

Genotype
MGI:4868429

cx3

• Allelic Composition: Mmp14^tm1Hbh/Mmp14^tm1Hbh; Mmp15^tm1Kohl/Mmp15^tm1Kohl
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:167396 )

• mice die between E10.5 and E11.5

embryo

embryonic growth retardation ( J:167396 )

• at E10.5

decreased embryo size ( J:167396 )

• at E10.5

abnormal placenta labyrinth morphology ( J:167396 )

• establishment of the labyrinthin layer of embryonic and maternal vascular interchange is retarded compared to in wild-type mice

• trophoblasts are present mostly as compact undifferentiated chorionic trophoblasts and far fewer as syncytiotrophoblast compared to in wild-type mice

• at E10.5, mice exhibit disruption of the labyrinth architecture compared with wild-type mice

abnormal placental labyrinth vasculature morphology ( J:167396 )

• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:167396 )

• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice

dilated vasculature ( J:167396 )

• at E10.5

enlarged pericardium ( J:167396 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:167396 )

• at E10.5

decreased embryo size ( J:167396 )

• at E10.5