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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmp14tm1.1Khol
targeted mutation 1.1, Kenn Holmbeck
MGI:4868413
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mmp14tm1Hbh/Mmp14tm1.1Khol
Mmp15tm1Kohl/Mmp15tm1Kohl
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA MGI:4868430


Genotype
MGI:4868430
cn1
Allelic
Composition		 Mmp14tm1Hbh/Mmp14tm1.1Khol
Mmp15tm1Kohl/Mmp15tm1Kohl
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1.1Khol mutation (0 available); any Mmp14 mutation (44 available)
Mmp14tm1Hbh mutation (0 available); any Mmp14 mutation (44 available)
Mmp15tm1Kohl mutation (0 available); any Mmp15 mutation (38 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal placental labyrinth vasculature morphology ( J:167396 )
• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice
absent placental labyrinth ( J:167396 )
• at E12.5 in tamoxifen-treated mice starting at E7.5
• however, placenta develops normally in mice treated with tamoxifen at E12.5

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:167396 )
N
• tamoxifen-treated mice exhibit normal mammary gland involution

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:167396 )
• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory