About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmp14tm1.1Khol
targeted mutation 1.1, Kenn Holmbeck
MGI:4868413
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mmp14tm1Hbh/Mmp14tm1.1Khol
Mmp15tm1Kohl/Mmp15tm1Kohl
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA MGI:4868430


Genotype
MGI:4868430
cn1
Allelic
Composition		 Mmp14tm1Hbh/Mmp14tm1.1Khol
Mmp15tm1Kohl/Mmp15tm1Kohl
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1.1Khol mutation (0 available); any Mmp14 mutation (44 available)
Mmp14tm1Hbh mutation (0 available); any Mmp14 mutation (44 available)
Mmp15tm1Kohl mutation (0 available); any Mmp15 mutation (38 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal placental labyrinth vasculature morphology ( J:167396 )
• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice
absent placental labyrinth ( J:167396 )
• at E12.5 in tamoxifen-treated mice starting at E7.5
• however, placenta develops normally in mice treated with tamoxifen at E12.5

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:167396 )
N
• tamoxifen-treated mice exhibit normal mammary gland involution

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:167396 )
• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory