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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr2tm2.1Ifc
targeted mutation 2.1, Israel F Charo
MGI:4868431
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1tm1Litt 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4868438
cx2
 		Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4868437


Genotype
MGI:4868438
cx1
Allelic
Composition		 Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm2.1Ifc mutation (2 available); any Ccr2 mutation (43 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )
• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis compared with similarly treated wild-type mice

hematopoietic system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice




Genotype
MGI:4868437
cx2
Allelic
Composition		 Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm2.1Ifc mutation (2 available); any Ccr2 mutation (43 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )
• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis with reduced monocyte infiltration into the central nervous system and decreased microglial cell activation compared with similarly treated wild-type mice

hematopoietic system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory