Phenotypes associated with this allele

• Allele Symbol: Ptbp1^tm1Msol
• Allele Name: targeted mutation 1, Michele Solimena
• Allele ID: MGI:4868473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptbp1^tm1Msol/Ptbp1^tm1Msol	B6J.129-Ptbp1^tm1Msol	MGI:5693895

Genotype
MGI:5693895

hm1

• Allelic Composition: Ptbp1^tm1Msol/Ptbp1^tm1Msol
• Genetic Background: B6J.129-Ptbp1^tm1Msol

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Ptbp1^tm1Msol/Ptbp1^tm1Msol embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:223915 )

• mice die between E8.5 and E12

embryo

abnormal gastrulation ( J:223915 )

• very few embryos exhibit partial separation of cell layers

abnormal endoderm development ( J:223915 )

• absence of squamous endodermal cells at E7.5

embryonic growth retardation ( J:223915 )

decreased embryo size ( J:223915 )

absent blastocoele ( J:223915 )

• embryos are not able to begin cavitation or properly form the yolk sac and the ectoplacental cone

abnormal ectoplacental cone morphology ( J:223915 )

• does not form properly

abnormal Reichert's membrane morphology ( J:223915 )

• membrane is not properly formed and contains an unusual amount of eosinophilic material

abnormal visceral yolk sac morphology ( J:223915 )

• in some mice, the yolk sac does not clearly separate from the epiblast

• delayed formation

growth/size/body

embryonic growth retardation ( J:223915 )

decreased embryo size ( J:223915 )

cellular

increased apoptosis ( J:223915 )

• in E7.5 embryos

decreased cell proliferation ( J:223915 )

• in E7.5 embryos